8 Best Drugstore Hand Creams: Dermatologist-Tested Picks 2025

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Best Value

2

Johnson & Johnson Sales

AVEENO Active Naturals Intense Relief Hand Cream 3.50 oz (Pack of 3)

9.6 Worth the Money

9.6 Long-lasting Effect

9.5 Skin Comfort

Why we love it

Clinically proven 24-hour moisturizing protection for dry skin

Dermatologist-recommended formula for reliable skincare results

Convenient 3.5-ounce tube size perfect for daily use

Main highlights

Key Features

Professional-grade hand cream offering clinical effectiveness, dermatologist approval, and 24-hour moisture protection in a convenient travel-friendly size.

Ideal for daily skin hydration and protection

Perfect for individuals seeking reliable daily hand care, especially those dealing with persistent dry skin conditions.

Praised for long-lasting moisture retention

Users consistently highlight the cream's ability to provide intense relief and maintain skin hydration throughout the entire day.

9.7

Exceptional

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3

O'Keeffe's Company

O'Keeffe's Working Hands Hand Cream; For Extremely Dry; Cracked Hands; 6.8 oz Jar (Value Size; Pack of 2)

Main highlights

Concentrated Hand Cream: O’Keeffe’s Working Hands Hand Cream is a dry hand repair cream that heals; relieves; soothes; and repairs extremely dry; cracked hands.
Hydrating Hand Cream: Creates a protective layer on the skin’s surface that locks in moisture and keeps your skin hydrated.
Leaves Skin Healthy & Soothed: O'Keeffe's dry hand cream makes a difference you will feel within days. When the hands that do the fixing need fixing turn to a workers hand cream.
For Best Results: Apply after hand washing; after bathing; and at bedtime; as these are the most effective times for effectively moisturizing extremely dry skin.
Safe for People with Diabetes: O'Keeffe's Working Hands is safe for people with diabetes; also hypoallergenic; unscented and non-greasy. #1 hand cream brand in America.*

9.4

Exceptional

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4

Beiersdorf

Eucerin Advanced Repair Hand Cream, Lotion for Very Dry Skin Use After Washing with Hand Soap, Fragrance Free, 2.7 oz, 12 Count (Pack of 4)

Main highlights

Advanced repair hand cream’s formula helps repair dry skin and provide the moisture that hands and fingers crave
Formulated with ceramide-3, natural moisturizing factors and nourishing shea butter
Frequent washing and external factors like the environment can strip hands of vital elements needed to keep hands soft, smooth and hydrated. Advanced repair hand cream leaves hands noticeably softer and smoother after just 1 application
Noticeably smoother hands after just 1 use
Non-greasy, fast-absorbing, fragrance and dye free