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8 Best Drugstore Hand Creams: Dermatologist-Tested Picks 2025

Fact checked by Olivia Williams
Last Updated January 8, 2025
Editor's Choice
1
Neutrogena Norwegian Formula Moisturizing Hand Cream Formulated with Glycerin for Dry, Rough Hands, Fragrance-Free Intensive Hand Lotion, 2 oz, 6 Pack

Kenvue

Neutrogena Norwegian Formula Moisturizing Hand Cream Formulated with Glycerin for Dry, Rough Hands, Fragrance-Free Intensive Hand Lotion, 2 oz, 6 Pack

9.8 Worth the Money
9.7 Long-lasting Relief
9.5 Skin Absorption

Why we love it

Concentrated glycerin formula provides 200+ applications per tube for lasting hydration
Dermatologist-recommended Norwegian formula effectively relieves dry, rough hands
Fragrance-free moisturizing cream requires only small amount for immediate relief

Main highlights

Key Features

Features concentrated glycerin formula, dermatologist-recommended Norwegian blend, and fragrance-free composition for effective dry skin relief.

Ideal for Daily Hand Care Protection

Perfect for maintaining hand moisture throughout daily activities, overnight treatment, and protection against harsh environmental conditions.

Praised for Superior Moisturizing Formula

Customers appreciate the concentrated formula requiring minimal product use, long-lasting moisture, and effective relief for rough hands.

9.9

Good

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Best Value
2
AVEENO Active Naturals Intense Relief Hand Cream 3.50 oz (Pack of 3)

Johnson & Johnson Sales

AVEENO Active Naturals Intense Relief Hand Cream 3.50 oz (Pack of 3)

9.6 Worth the Money
9.6 Long-lasting Effect
9.5 Skin Comfort

Why we love it

Clinically proven 24-hour moisturizing protection for dry skin
Dermatologist-recommended formula for reliable skincare results
Convenient 3.5-ounce tube size perfect for daily use

Main highlights

Key Features

Professional-grade hand cream offering clinical effectiveness, dermatologist approval, and 24-hour moisture protection in a convenient travel-friendly size.

Ideal for daily skin hydration and protection

Perfect for individuals seeking reliable daily hand care, especially those dealing with persistent dry skin conditions.

Praised for long-lasting moisture retention

Users consistently highlight the cream's ability to provide intense relief and maintain skin hydration throughout the entire day.

9.7

Exceptional

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3
O'Keeffe's Working Hands Hand Cream; For Extremely Dry; Cracked Hands; 6.8 oz Jar (Value Size; Pack of 2)

O'Keeffe's Company

O'Keeffe's Working Hands Hand Cream; For Extremely Dry; Cracked Hands; 6.8 oz Jar (Value Size; Pack of 2)

Main highlights

  • Concentrated Hand Cream: O’Keeffe’s Working Hands Hand Cream is a dry hand repair cream that heals; relieves; soothes; and repairs extremely dry; cracked hands.
  • Hydrating Hand Cream: Creates a protective layer on the skin’s surface that locks in moisture and keeps your skin hydrated.
  • Leaves Skin Healthy & Soothed: O'Keeffe's dry hand cream makes a difference you will feel within days. When the hands that do the fixing need fixing turn to a workers hand cream.
  • For Best Results: Apply after hand washing; after bathing; and at bedtime; as these are the most effective times for effectively moisturizing extremely dry skin.
  • Safe for People with Diabetes: O'Keeffe's Working Hands is safe for people with diabetes; also hypoallergenic; unscented and non-greasy. #1 hand cream brand in America.*

9.4

Exceptional

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4
Eucerin Advanced Repair Hand Cream, Lotion for Very Dry Skin Use After Washing with Hand Soap, Fragrance Free, 2.7 oz, 12 Count (Pack of 4)

Beiersdorf

Eucerin Advanced Repair Hand Cream, Lotion for Very Dry Skin Use After Washing with Hand Soap, Fragrance Free, 2.7 oz, 12 Count (Pack of 4)

Main highlights

  • Advanced repair hand cream’s formula helps repair dry skin and provide the moisture that hands and fingers crave
  • Formulated with ceramide-3, natural moisturizing factors and nourishing shea butter
  • Frequent washing and external factors like the environment can strip hands of vital elements needed to keep hands soft, smooth and hydrated. Advanced repair hand cream leaves hands noticeably softer and smoother after just 1 application
  • Noticeably smoother hands after just 1 use
  • Non-greasy, fast-absorbing, fragrance and dye free

9.2

Excellent

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5
Homecourt Hand Cream - Non-Greasy Moisturizer Soothes and Softens Hands Dermatologist Tested. 12 Fl Oz Cipres Mint

Homecourt

Homecourt Hand Cream - Non-Greasy Moisturizer Soothes and Softens Hands Dermatologist Tested. 12 Fl Oz Cipres Mint

9.0 Worth the Money
9.0 Hydration Quality
8.9 Non-Greasy Formula

Why we love it

Clinically tested formula with natural Australian hibiscus for deep hydration
Advanced fermented micro algae oil technology for skin repair
Lightweight, non-greasy texture providing intense moisture and protection

Main highlights

Key Features

Combines premium botanical extracts with dermatologist-tested formula, offering superior hydration and skin repair benefits.

Ideal for dry and damaged skin care

Perfect for those seeking intensive moisture without heaviness, especially during seasonal skin changes and harsh weather conditions.

Praised for professional-grade hydration

Users consistently praise its lightweight yet deeply moisturizing formula, backed by dermatologist certification and natural ingredients.

9.0

Excellent

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6
AHAVA Dead Sea Mineral Hand Cream, Original, Hand Moisturizer For Dry Cracked Hands, Light and Fast Absorbing, For All Skin Types 5.1 Fl Oz.

AHAVA

AHAVA Dead Sea Mineral Hand Cream, Original, Hand Moisturizer For Dry Cracked Hands, Light and Fast Absorbing, For All Skin Types 5.1 Fl Oz.

8.8 Gentle on Skin
8.6 Dermatologically Safe
8.4 Value for Money

Why we love it

Specially formulated without parabens for sensitive skin protection and care
Thoroughly tested by dermatologists and validated for allergy safety
Limited edition offers 50% more product value for extended use

Main highlights

Key Features

Paraben-free formula with dermatologist approval, allergy testing certification, and generous limited edition bonus quantity offering superior value.

Ideal for sensitive and allergy-prone skin

Perfect for individuals with sensitive skin conditions seeking a gentle, dermatologist-approved skincare solution for daily use.

Praised for gentle and safe formulation

Users consistently praise the product's gentle formulation, making it a trusted choice for those with sensitive skin concerns.

8.9

Excellent

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7
L’Occitane Shea Butter Hand Cream 5.1 Oz: Nourishes Very Dry Hands, Protects Skin, With 20% Organic Shea Butter, Vegan, 1 Sold Every 3 Seconds*

L'OCCITANE

L’Occitane Shea Butter Hand Cream 5.1 Oz: Nourishes Very Dry Hands, Protects Skin, With 20% Organic Shea Butter, Vegan, 1 Sold Every 3 Seconds*

8.6 Worth the Money
8.6 Easy to Apply
8.4 Moisturizing Effect

Why we love it

20% organic shea butter formula deeply nourishes and protects dry hands
Vegan-friendly hand cream with quick-absorbing, non-greasy formula
Award-winning moisturizer that leaves hands soft and smooth

Main highlights

Key Features

Premium hand cream featuring organic shea butter, vegan ingredients, and fast-absorbing formula for effective hand care.

Ideal for dry and damaged hands

Perfect for those with dry, cracked hands seeking deep nourishment and protection throughout daily activities.

Praised for exceptional moisturizing properties

Customers love the non-greasy texture and lasting moisturizing effects that leave hands feeling soft and well-protected.

8.7

Excellent

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8
L’OCCITANE Nourishing Intensive Hand Balm: With 25% Organic Shea Butter, Intense Nourishment, Vegan, 5.2 Oz

L'Occitane

L’OCCITANE Nourishing Intensive Hand Balm: With 25% Organic Shea Butter, Intense Nourishment, Vegan, 5.2 Oz

Main highlights

  • An ultra- rich version of the iconic Shea Hand Cream with 25% shea butter, specially adapted for very dry skin.

8.5

Very Good

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9
L'OCCITANE Immortelle Shea Youth Hand Cream: Anti-Aging, Nourish with Shea Butter, Improve Skin Elasticity with Immortelle Essential Oil

AmazonUs/LOCAH

L'OCCITANE Immortelle Shea Youth Hand Cream: Anti-Aging, Nourish with Shea Butter, Improve Skin Elasticity with Immortelle Essential Oil

Main highlights

  • Reduces the appearance of wrinkles Visibly improves skin elasticity Helps reduce the appearance of dark spots Nourishes hands Brightens hands
  • Hydrated Skin
  • REDUCING THE APPEARANCE OF UNEVEN SKIN TONE

8.4

Very Good

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10
Clarins Super Restorative Hand Cream | Anti-Aging | Targets Dark Spots and Wrinkles | Promotes Youthful-Looking Hands Immediately and Over Time | Shea and Mango Butters Nourish, Soften and Smoothe

Clarins

Clarins Super Restorative Hand Cream | Anti-Aging | Targets Dark Spots and Wrinkles | Promotes Youthful-Looking Hands Immediately and Over Time | Shea and Mango Butters Nourish, Soften and Smoothe

Main highlights

  • Promote youthful-looking hands over time. This deeply replenishing hand cream for mature skin weakened by hormonal changes targets signs of aging with Organic Harungana and nourishes with Shea and Mango butters.
  • A daily anti-aging hand cream that targets dark spots, deep wrinkles, age spots and loss of density.
  • Recommended for younger to mature skin and for all skin types.

8.2

Very Good

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Onsen Japanese Anti Aging Hand Cream - Firming Hand Lotion Features Pagoda Flower Enzyme, Wasabi Extract Infusion, Hyaluronic Acid, and Shea Butter, for Clarified and Moisture Rich Skin (4.5 Oz)

Onsen Japanese Anti Aging Hand Cream - Firming Hand Lotion Features Pagoda Flower Enzyme, Wasabi Extract Infusion, Hyaluronic Acid, and Shea Butter, for Clarified and Moisture Rich Skin (4.5 Oz)

$36.00
Sacubee Christian Hand Cream Bulk Christmas Gifts for Women Bible Verse Hand Lotion Scripture Travel Hand Lotion for Dry Cracked Hands Bulk Gifts for Mom Grandma Breast Cancer(72 Pcs,Cross Style)

Sacubee Christian Hand Cream Bulk Christmas Gifts for Women Bible Verse Hand Lotion Scripture Travel Hand Lotion for Dry Cracked Hands Bulk Gifts for Mom Grandma Breast Cancer(72 Pcs,Cross Style)

$31.99
$33.99
Awakening Hands - Magnesium-Rich Hydrating Hand Therapy Hand Cream - Moisturizing Hand Lotion with Myrrh- 250ml/8.5oz Countertop Airless Pump

Awakening Hands - Magnesium-Rich Hydrating Hand Therapy Hand Cream - Moisturizing Hand Lotion with Myrrh- 250ml/8.5oz Countertop Airless Pump

$58.00
O'Keeffe's Working Hands Hand Cream for Extremely Dry; Cracked Hands; 3.4 Ounce Jar; (Pack 12)

O'Keeffe's Working Hands Hand Cream for Extremely Dry; Cracked Hands; 3.4 Ounce Jar; (Pack 12)

$99.96
$114.02